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Subject cui: C0120465 Name: Guanine Nucleotide Exchange Factors Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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Guanine Nucleotide Exchange Factors STIMULATES CDC42|CDC42 gene Correct? #Y/N
Like other small GTP-binding proteins, CDC42 is activated by a guanosine exchange factor and inactivated by a GTPase-activating protein (GAP). (PMID: 8253717) 0/0
Chemokine-driven TEM also uses ZAP-70, albeit in a quantitatively and spatially different manner of activation, and is independent of Vav, Rac, and mysosin IIA, depending instead on an as-yet unidentified GTP exchange factor that activates Cdc42 . (PMID: 23420881) 0/0
FGD1 encodes a guanine nucleotide exchange factor that specifically activates the GTPase Cdc42 . (PMID: 19261807) 0/0
FGD1 encodes a guanine nucleotide exchange factor that specifically activates Cdc42 , a Rho family small GTPase that regulates a variety of cellular behaviors. (PMID: 21356349) 0/0
In budding yeast, Cdc42 is activated by a single guanine nucleotide exchange factor, Cdc24. (PMID: 19668330) 0/0
In previous studies we have shown that Dbs is a Rho-specific guanine nucleotide exchange factor that can activate RhoA and/or Cdc42 in a cell-specific manner. (PMID: 16613852) 0/0
First, we determined that RhoG was regulated by guanine nucleotide exchange factors that also activate Rac and/or Cdc42 . (PMID: 12376551) 0/0
Dbl is a guanine nucleotide exchange factor that activates the Rho family GTPases Cdc42 , Rac, and Rho. (PMID: 11337492) 0/0
FGD1, the gene responsible for faciogenital dysplasia, encodes a guanine nucleotide exchange factor that specifically activates Cdc42 , a member of the Rho (Ras homology) family of p21 GTPases. (PMID: 9268645) 0/0
XGef is a Rho-family guanine nucleotide exchange factor and activates Cdc42 in mammalian cells. (PMID: 12648498) 0/0
Ras1 interacts with Ral1/Scd1, a putative guanine-nucleotide-exchange factor , which could activate Cdc42 , Rho-like GTP-binding protein. (PMID: 7548847) 0/0
FGD1 encodes a guanine nucleotide exchange factor (GEF) that specifically activates the Rho GTPase CDC42 . (PMID: 21965325) 0/0
Collybistin (CB) is a guanine-nucleotide-exchange factor (GEF) selectively activating Cdc42 . (PMID: 21807943) 0/0
Members of the Fgd (faciogenital dysplasia) gene family encode a group of critical guanine nucleotide exchange factors (GEFs), which, by specifically activating Cdc42 , control cytoskeleton-dependent membrane rearrangements. (PMID: 18838382) 0/0
Dock6 is a guanine nucleotide exchange factor (GEF) that activates the Rho family guanosine triphosphatases Rac1 and Cdc42 to regulate the actin cytoskeleton. (PMID: 23462102) 0/0
CONCLUSIONS: These data suggest that Zizimin2 is an immune-related and age-regulated guanine nucleotide exchange factor , which facilitates filopodial formation through activation of Cdc42 , which results in activation of cell migration. (PMID: 22494997) 0/0
Using RNA interference combined with re-introduction experiments, we identified FGD4 (FYVE, RhoGEF and PH domain containing 4) as the GEF (guanine nucleotide exchange factor ) responsible for the activation of Cdc42 by LMP1. (PMID: 22589722) 0/0
FGD1 encodes a guanine nucleotide exchange factor (GEF) that specifically activates the Rho GTPase Cdc42 ; (PMID: 10906777) 0/0
The Salmonella effector SopE is a guanine nucleotide exchange factor (GEF) that activates Rac1 and Cdc42 , which induce "the trigger mechanism of cell entry." (PMID: 20123714) 0/0
FGD1 encodes a guanine nucleotide exchange factor (GEF) that specifically activates the Rho GTPase Cdc42 . (PMID: 10458911) 0/0
FGD1 encodes a guanine nucleotide exchange factor (GEF) that specifically activates the Rho GTPase Cdc42 . (PMID: 11751687) 0/0
FGD1 and Fgd1, the mouse FGD1 ortholog, encode guanine nucleotide exchange factors (GEF) that specifically activate Cdc42 , a Rho GTPase that controls the organization of the actin cytoskeleton. (PMID: 12913069) 0/0
Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42 . (PMID: 16968698) 0/0
Dbs is a guanine nucleotide exchange factor which is expressed throughout thymocyte development and is able to activate the Rho family GTPases CDC42 , RhoA and RhoG. (PMID: 14991610) 0/0
FGD1 encodes a guanine nucleotide exchange factor (GEF) that specifically activates the Rho GTPase Cdc42 . (PMID: 10721717) 0/0
Rho family guanine nucleotide exchange factors (GEFs) (also known as Dbl family proteins) that activate CDC42 , Rac1, and RhoA also demonstrate oncogenic potential. (PMID: 9671479) 0/0
Consistently, activation of Cdc42 by overexpression of Tuba, a Golgi-associated guanine nucleotide exchange factor for Cdc42 increased the number of intracellular dense-core vesicles, whereas inhibition of Cdc42 by overexpression of the Cdc42/Rac interactive binding domain of neuronal Wiskott-Aldrich syndrome protein decreased the number of them. (PMID: 22426478) 0/0