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Subject cui: C0106751 Name: BN 52021 Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C0071234|9768 Name: KIAA0101|platelet activating factor receptor Sem. type: gngm|aapp Novel: true

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BN 52021 INHIBITS KIAA0101|platelet activating factor receptor Correct? #Y/N
BN 52021 , a new specific PAF-acether receptor antagonist , was evaluated on several cardiovascular models. (PMID: 3763677) 0/0
BN 52021 , PAF-receptor antagonist , improves diminished antioxidant defense system of lungs in experimentally induced haemorrhagic shock. (PMID: 9861635) 0/0
The animals of groups III and IV received respectively intravenous indomethacin (3 mg kg-1) and BN 52021 (3 mg kg-1), a paf receptor antagonist before the sequence heparin-protamine. (PMID: 1628640) 0/0
The material produced by epidermal cells was identical to synthetic paf because: 1) the aggregation of aspirin-treated and ADP-insensitive washed rabbit platelets it induced was inhibited by BN 52021 , an antagonist of the paf putative receptor ; (PMID: 2230220) 0/0
Administration during the plateau or pretreatment with liposomes containing BN 52021 (3-t-butylhexahydro-4,7b-trihydroxy-8-methyl-9H-1,7a-epoxymethano- 1H,6aH- cyclopenta[c]furo(2,3-b)furo[3',2':3,4]cyclopental [1,2-d]furan-5,9,12(4H)-trione) ((10(-3) M, a selective PAF receptor antagonist ) or heparin (5 x 10(-5) M) blocked this contraction. (PMID: 8566122) 0/0
In order to clarify the pathological importance of icosanoids and PAF-acether in the septicemic process, we investigated the effects of indomethacin (IND) a cyclooxygenase inhibitor, NDGA and EP 10045 two lipoxygenase inhibitors, dexamethasone (DXM) a phospholipase A2 inhibitor and BN 52021 a PAF-acether receptor antagonist , on the Salmonella enteritidis-induced endotoxic shock (E.S.) in the rat. (PMID: 3774851) 0/0
The effects of BN 52021 , a new specific paf-acether receptor antagonist and the total Ginkgo Biloba extract (GBE 761) from which this product was isolated, were studied in the rat on paf-acether-induced permeability and cell number changes and on endotoxin-induced lethality. (PMID: 3515870) 0/0
All these impairments except tachycardia were decreased by BN 52021 , a specific PAF-acether receptor antagonist , applied in a constant infusion before ovalbumin challenge. (PMID: 3780855) 0/0
When fibroblasts in suspension (1 X 10(6) cells) were stimulated with 2 microM Ca1+ ionophore A23187 (Io), they synthesized a material that aggregated aspirin-treated washed rabbit platelets and was identified as paf because 1) the platelet aggregation it induced was inhibited by BN 52021 , an antagonist of paf putative receptors ; (PMID: 3397536) 0/0
BN 52021 , a specific PAF-acether receptor antagonist , reversed by more than 70% the increase of inhibition of LPS-induced IL1 release and synthesis induced by 1pM and 0.1 microM of the autacoid, respectively. (PMID: 3313526) 0/0
The purpose of our experiments was to determine whether BN 52021 , PAF-receptor antagonist , has any influence on the production of reactive oxygen species in the lung induced by haemorrhagic shock. (PMID: 9861635) 0/0