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Subject cui: C0009035 Name: Clorgyline Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C0026455|4128 Name: MAOA|Monoamine Oxidase A Sem. type: gngm|aapp Novel: true

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Clorgyline INHIBITS MAOA|Monoamine Oxidase A Correct? #Y/N
Depletion of noradrenaline in locus coeruleus neurons after reserpinization was prevented by clorgyline , a selective inhibitor of MAO A , but not by deprenyl, a selective inhibitor of MAO B. (PMID: 2513220) 0/0
Loosely based upon the structure of clorgyline , it is an irreversible inhibitor of MAO A but is apparently indifferent towards MAO B. (PMID: 7126245) 0/0
In rats bearing unilateral 6-hydroxydopamine lesions of the nigro-striatal dopamine pathways, both MDL 72145 and clorgyline , a selective inhibitor of MAO A , augmented the contralateral turning response to L-DOPA combined with carbidopa. (PMID: 3082400) 0/0
Moreover, the increases of noradrenaline and serotonin and the decreases of their metabolites MHPG-SO4 and 5-HIAA were smaller after CGP 11305 A than after clorgyline in equieffective doses for MAO A inhibition . (PMID: 6195533) 0/0
This contrasts with a recent report that [11C]clorgyline (in contrast to other labeled MAO A inhibitors ) is not retained in the rhesus monkey brain [4]. (PMID: 11578898) 0/0