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Subject cui: C0005117 Name: Berberine Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C1333203|1616 Name: DAXX|DAXX gene Sem. type: gngm|gngm Novel: true

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Berberine INHIBITS DAXX|DAXX gene Correct? #Y/N
Following studies demonstrated a possible mechanism that BBR inhibited the DAXX promoter activity through blocking or disrupting the association of Sp1 or Ets1 and their consensus sequences in the promoter. (PMID: 23295648) 0/0
Here, we further investigate the mechanisms underlying the transcriptional suppression of DAXX by BBR. (PMID: 23295648) 0/0
Downregulation of DAXX by BBR resulted in inhibition of MDM2 and subsequently, activation of p53, leading to cancer cell death. (PMID: 23295648) 0/0
Our results reveal a novel possible mechanism: by competitively binding to the Sp1 and Ets1 consensus sequences, BBR inhibits the transcription of DAXX , thus inducing cancer cell apoptosis through a p53-dependent pathway. (PMID: 23295648) 0/0