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Subject cui: C0073096 Name: resveratrol Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C0909868|26206|26871 Name: SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Sem. type: gngm|gngm|aapp Novel: true

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resveratrol INHIBITS SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Correct? #Y/N
The kinetic study revealed that resveratrol acted as a non-competitive inhibitor of 11beta-HSD1 . (PMID: 23814014) 0/0
We demonstrated that the antiobesity effects of resveratrol may partially be attributed to the inhibition of 11beta-HSD1 activity in adipocytes. (PMID: 23814014) 0/0
Significant inhibition of 11beta-HSD1 by resveratrol was observed in rat adipose microsomes and 3T3-L1 adipocytes within 10 min. (PMID: 23814014) 0/0
These results suggest that the most likely mechanism of 11beta-HSD1 inhibition by resveratrol is via interaction between resveratrol and 11beta-HSD1 enzyme, rather than via a transcriptional pathway. (PMID: 23814014) 0/0