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Subject cui: C1565434 Name: Focal Adhesion Protein-Tyrosine Kinases Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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Focal Adhesion Protein-Tyrosine Kinases STIMULATES CDC42|CDC42 gene Correct? #Y/N
At the molecular level, TG-2 knockdown reduced phosphorylation of beta-3 integrin at Tyr747, paxillin at Ser178, vinculin at Tyr822 and focal adhesion kinase at Tyr925 simultaneous with reduced activation of Rac and CDC42 . (PMID: 23466867) 0/0
In addition, the activation of Rac1 and Cdc42 by human laminin-2-integrin-dependent activation of PKCdelta/FAK signaling mediates cell spreading and lamellipodia formation in PC12 cells. (PMID: 23063429) 0/0
In addition, knockdown and overexpression of Ten-4 reduced and elevated the activation of focal adhesion kinase (FAK) and Rho-family small GTPases, Cdc42 and Rac1, key molecules for the membranous protrusion formation downstream of FAK, respectively. (PMID: 24344332) 0/0
Infection of cells stably expressing integrin-beta1 variants with well-known defects in fibronectin fibril formation or FAK signaling also exhibited severe deficiencies in Cdc42 activation and bacterial invasion. (PMID: 22204307) 0/0