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Subject cui: C0694888|5728 Name: PTEN|PTEN gene Sem. type: gngm|gngm Novel: true

Predicate: INHIBITS

Object cui: C0812240|648 Name: BMI1|BMI1 gene Sem. type: gngm|gngm Novel: true

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PTEN|PTEN gene INHIBITS BMI1|BMI1 gene Correct? #Y/N
PTEN inhibits BMI1 function independently of its phosphatase activity. (PMID: 19903340) 0/0
The nuclear protein BMI1 promotes stem cell self-renewal and tumorigenesis and PTEN inhibits these events, suggesting that PTEN may suppress BMI1 function. (PMID: 19903340) 0/0
RESULTS: We investigated whether PTEN inhibits BMI1 function during prostate tumorigenesis. (PMID: 19903340) 0/0
Furthermore, knockdown of PTEN in DU145 cells increased hTERT promoter activity, which was reversed when BMI1 was concomitantly knocked-down, indicating that PTEN reduces hTERT promoter activity via inhibiting BMI1 function. (PMID: 19903340) 0/0
CONCLUSION: We demonstrate that nuclear PTEN reduces BMI1 function independently of its phosphatase activity. (PMID: 19903340) 0/0