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Subject cui: C0017710 Name: Glucocorticoids Sem. type: horm Novel: true

Predicate: INHIBITS

Object cui: C0909868|26206|26871 Name: SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Sem. type: gngm|gngm|aapp Novel: true

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Glucocorticoids INHIBITS SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Correct? #Y/N
Because of the circadian variation of plasma glucocorticoids , the pharmacological efficacy of 11beta-HSD1 inhibition may depend on the time of the day for inhibitor administration. (PMID: 18479468) 0/0
Femoral artery wire angioplasty was conducted in C57BL/6J, Apo-E(-/-), 11beta-HSD1(-/-), Apo-E, 11beta-HSD1(-/-) (double knockout), and 11beta-HSD2(-/-) mice after glucocorticoid administration, adrenalectomy, glucocorticoid or mineralocorticoid receptor antagonism, or selective 11beta-HSD1 inhibition . (PMID: 23125311) 0/0
Here, we review research findings that support a key role for GCs with special emphasis on their intracellular regulation by 11beta-HSD1 in the emergence of spatial memory deficits with aging, and discuss the use of 11beta-HSD1 inhibitors as a promising novel treatment in ameliorating/improving age-related memory impairments. (PMID: 22952463) 0/0
Our findings demonstrate that 11beta-HSD1 activates considerably more corticosterone than is generated de novo from progesterone in mouse skin and drives GC exposure during healing, demonstrating the basis for 11beta-HSD1 inhibitors to accelerate wound repair. (PMID: 24464022) 0/0
However, any impact of 11beta-HSD1 inhibition during high glucocorticoid states in younger animals is unknown. (PMID: 24495397) 0/0