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Subject cui: C0694888|5728 Name: PTEN|PTEN gene Sem. type: gngm|gngm Novel: true

Predicate: INHIBITS

Object cui: 4734 Name: NEDD4 Sem. type: gngm Novel: true

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DeltaNp63alpha represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes. (PMID: 23589096) 0/0
Altogether, these studies suggest that DeltaNp63alpha-mediated suppression of nuclear PTEN in basal layer keratinocytes occurs through repression of NEDD4-1 . (PMID: 23589096) 0/0
The decrease in ubiquitinated PTEN correlated with the ability of DeltaNp63alpha to bind to neuronal precursor developmentally down regulated 4 (NEDD4) promoter and transcriptionally repress the E3 ubiquitin ligase NEDD4-1 . (PMID: 23589096) 0/0
We further demonstrate that PTEN, a negative regulator of the PI3K pathway, is a key downstream target of Nedd4: not only does Nedd4 regulate PTEN levels in RGC growth cones, but also, the decrease of PTEN rescues the branching defect caused by Nedd4 inhibition . (PMID: 20159448) 0/0