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Subject cui: C0164786|207 Name: AKT1|Proto-Oncogene Proteins c-akt Sem. type: gngm|aapp Novel: true

Predicate: INHIBITS

Object cui: C0599933|5970|6857|64689|65125 Name: RELA|SYT1|GORASP1|WNK1|p65 Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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AKT1|Proto-Oncogene Proteins c-akt INHIBITS RELA|SYT1|GORASP1|WNK1|p65 Correct? #Y/N
The livers of all HO-1 overexpressing mice had activation of nuclear phospho-p38 mitogen-activated protein kinase (MAPK) and phospho-Akt , decreased nuclear expression of nuclear factor-kappa B (NF-kappaB) p65 , and decreased soluble vascular cell adhesion molecule-1 (sVCAM-1) in serum. (PMID: 20306336) 0/0
Pre-treatment with MHY884 inhibited Akt and IkappaB kinase alpha/beta signaling pathways, leading to decreased translocation and phosphorylation of p65 , a subunit of NF-kappaB. (PMID: 24508132) 0/0
Inhibition of PTEN by siRNAs restored miR-21 Sponge-induced suppression of phosphorylation of p65, IKKbeta, IkappaB and NFkappaB transcriptional activity along with reversal of miR-21 Sponge-reduced phosphorylation of Akt. (PMID: 23981302) 0/0