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Subject cui: C0021641|3630 Name: INS|Insulin Sem. type: gngm|aapp Novel: true

Predicate: INHIBITS

Object cui: C1424661|10628 Name: TXNIP|TXNIP gene Sem. type: gngm|gngm Novel: true

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INS|Insulin INHIBITS TXNIP|TXNIP gene Correct? #Y/N
CONCLUSIONS/INTERPRETATION: Insulin is a potent repressor of TXNIP , operating a negative feedback loop that restrains the stimulation of TXNIP by chronic hyperglycaemia. (PMID: 19214472) 0/0
Repression of TXNIP by insulin is probably an important compensatory mechanism protecting beta cells from oxidative damage and apoptosis in type 2 diabetes. (PMID: 19214472) 0/0
In contrast, adding insulin to the culture medium or stimulating insulin secretion with different secretagogues suppressed TXNIP . (PMID: 19214472) 0/0