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Subject cui: C0013982 Name: Emodin Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C0909868|26206|26871 Name: SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Sem. type: gngm|gngm|aapp Novel: true

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Emodin INHIBITS SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Correct? #Y/N
Single oral administration of emodin inhibited 11beta-HSD1 activity of liver and fat significantly in mice. (PMID: 20718744) 0/0
RESULTS: Emodin inhibited the 11beta-HSD1 activity in 3T3-L1 adipocytes in concentration- and time-dependent manners (the IC50 values were 7.237 and 4.204 mumol/L, respectively, after 1 and 24 h treatment. In 3T3-L1 adipocytes, emodin (30 mumol/L) suppressed 11-dehydrocorticosterone-induced adipogenesis without affecting corticosterone-induced adipogenesis; (PMID: 22922341) 0/0
CONCLUSION: Emodin improves the inactive glucocorticoid-induced adipose tissue dysfunction by selective inhibition on 11beta-HSD1 in adipocyte in vitro and improves glycemic control in ob/ob mice. (PMID: 22922341) 0/0
KEY RESULTS: Emodin is a potent and selective 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively. (PMID: 20718744) 0/0