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Subject cui: C0066672 Name: mocimycin Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C0300140|1915 Name: EEF1A1|EEF1A1 protein, human Sem. type: gngm|aapp Novel: true

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mocimycin INHIBITS EEF1A1|EEF1A1 protein, human Correct? #Y/N
33:322-325, 1989), the elongation factor Tu (EF-Tu) from Staphylococcus aureus was found to be insensitive to a series of kirromycin analogs which were inhibitory to the EF-Tu from Escherichia coli. (PMID: 1839491) 0/0
The antibiotic kirromycin , known to block EF-Tu function, inhibits the modification. (PMID: 7782317) 0/0
Kirromycin , a known inhibitor of EF-Tu , was positive in this screen. (PMID: 9066762) 0/0
The steps following GTP hydrolysis--the switch of EF-Tu to the GDP-bound conformation, the release of aminoacyl-tRNA from EF-Tu to the A site, and the dissociation of EF-Tu-GDP from the ribosome--which are altogether suppressed by kirromycin, are not distinguished kinetically. (PMID: 7781613) 0/0
By using inhibitors of elongation factor Tu (L-1-tosylamido-2-phenylethyl chloromethyl ketone [TPCK] and kirromycin ), we determined the effect of elongation factor Tu inhibition on the synthesis of individual components of the translation machinery. (PMID: 355239) 0/0