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Subject cui: C0021641 Name: Insulin Sem. type: aapp Novel: true

Predicate: INHIBITS

Object cui: 79602 Name: ADIPOR2 Sem. type: gngm Novel: true

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Insulin INHIBITS ADIPOR2 Correct? #Y/N
In primary cultured neonatal rat ventricular myocytes (NRVMs), insulin decreased AdipoR1 but not AdipoR2 expression and AMPK phosphorylation; (PMID: 22012952) 0/0
Using the phosphatidylinositol 3-kinase inhibitor (PI3K inhibitor, LY 294002), we found that insulin inhibited the expression of AdipoR2 through the PI3K pathway and this inhibition was blocked by addition of rosiglitazone. (PMID: 18054196) 0/0
When porcine adipocytes were cultured without insulin, supplementation with 10 nM insulin inhibited the expression of AdipoR2 and this inhibition effect was also blocked by addition of rosiglitazone. (PMID: 18054196) 0/0