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Subject cui: C0701303 Name: R-38486 Sem. type: phsu Novel: true

Predicate: INHIBITS

Object cui: C0909868|26206|26871 Name: SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Sem. type: gngm|gngm|aapp Novel: true

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R-38486 INHIBITS SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Correct? #Y/N
CBX treatment inhibited the stimulatory effects of BPA (at 10 nM) on PPAR-gamma and LPL mRNA expression, whereas RU486 inhibited 11beta-HSD1 mRNA expression in the adipocytes. (PMID: 23090578) 0/0
Incubation of mouse primary hepatocytes with corticosterone enhanced G6PT and H6PDH production with corresponding activation of 11beta-HSD1 and PEPCK: effects that were blocked by RU486. (PMID: 21052977) 0/0
RU486 (mifepristone, 11beta-[p-(dimethylamino)phenyl]-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-o ne), a glucocorticoid receptor antagonist, decreased adipose mRNA levels of 11beta-HSD1 as well as adipose triglyceride lipase. (PMID: 24511146) 0/0