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Subject cui: C0079419|7157 Name: TP53|TP53 gene Sem. type: gngm|gngm Novel: true


Object cui: C0022457|3845 Name: KRAS|K-ras Oncogene Sem. type: gngm|gngm Novel: true

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TP53|TP53 gene STIMULATES KRAS|K-ras Oncogene Correct? #Y/N
Our approach combined mosaic mouse models, Cre-lox technology, and in vivo RNAi to disable p53 and simultaneously activate endogenous Kras (G12D)-a common AML lesion that promotes proliferation but not self-renewal. (PMID: 20595231) 0/0
Lentiviral-mediated somatic activation of oncogenic Kras and deletion of p53 in the lung epithelial cells of Kras(LSL-G12D/+);p53(flox/flox) mice initiates lung adenocarcinoma development. (PMID: 21471965) 0/0
Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia. (PMID: 24058630) 0/0
Here, we evaluated the role of the splenic reservoir in a genetic mouse model of lung adenocarcinoma driven by activation of oncogenic Kras and inactivation of p53. (PMID: 22308361) 0/0
Inactivation of p53 or phosphatase and tensin homolog deleted from chromosome 10, or activation of Kras , promoted tumor development only in the context of APC suppression, consistent with earlier genetic studies. (PMID: 23776211) 0/0
Activation of oncogenic Kras mutations through inflammation, coupled with altered levels of tumor suppressor proteins (p53 and p16) can ultimately lead to development of pancreatic cancer. (PMID: 24474939) 0/0
Although a combination of four genetic alterations, including hTERT overexpression, inactivation of the pRB and p53 pathways, and KRAS activation , is insufficient for normal human small airway epithelial cells to be fully transformed, expression of one additional oncogene induces malignant transformation. (PMID: 21447735) 0/0
We quantified the competitive advantage of Apc loss, Kras activation, and P53 mutations in the mouse intestine. (PMID: 24264992) 0/0
Additional inactivation of p16, p53 , or transforming growth factor-beta signaling, in the context of Kras activation , dramatically accelerates mPanIN progression to invasive pancreatic ductal adenocarcinoma (PDAC) with abundant stromal expansion and marked fibrosis (desmoplasia). (PMID: 21611096) 0/0
Spontaneous missense mutation of tumor suppressor Trp53 arises subsequent to KRAS activation , but before grade III progression. (PMID: 24114272) 0/0