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Subject cui: C0006684 Name: Calcium Channel Blockers Sem. type: phsu Novel: true

Predicate: INHIBITS

Object cui: C1424661|10628 Name: TXNIP|TXNIP gene Sem. type: gngm|gngm Novel: true

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Calcium Channel Blockers INHIBITS TXNIP|TXNIP gene Correct? #Y/N
Surprisingly, testing putative TXNIP modulators revealed that calcium channel blockers reduce cardiomyocyte TXNIP transcription and protein levels in a dose-dependent manner. (PMID: 19258488) 0/0
We were surprised to discover that calcium channel blockers inhibited TXNIP expression in INS-1 cells and human islets and that orally administered verapamil reduced TXNIP expression and beta-cell apoptosis, enhanced endogenous insulin levels, and rescued mice from STZ-induced diabetes. (PMID: 22442301) 0/0
Here we have examined the causal role of TXNIP expression in mediating retinal neurotoxicity and assessed the neuroprotective actions of verapamil, a calcium channel blocker and an inhibitor of TXNIP expression. (PMID: 21434880) 0/0