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Subject cui: C0042523 Name: Verapamil Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C1424661|10628 Name: TXNIP|TXNIP gene Sem. type: gngm|gngm Novel: true

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Verapamil INHIBITS TXNIP|TXNIP gene Correct? #Y/N
We were surprised to discover that calcium channel blockers inhibited TXNIP expression in INS-1 cells and human islets and that orally administered verapamil reduced TXNIP expression and beta-cell apoptosis, enhanced endogenous insulin levels, and rescued mice from STZ-induced diabetes. (PMID: 22442301) 0/0
Here we have examined the causal role of TXNIP expression in mediating retinal neurotoxicity and assessed the neuroprotective actions of verapamil , a calcium channel blocker and an inhibitor of TXNIP expression. (PMID: 21434880) 0/0
Oral administration of verapamil for 3 wk also reduced cardiac TXNIP expression in mice even in the face of severe diabetes, and these reduced TXNIP levels were associated with decreased apoptosis. (PMID: 19258488) 0/0