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Subject cui: C0011185 Name: dehydroepiandrosterone Sem. type: horm Novel: true

Predicate: INHIBITS

Object cui: C0909868|26206|26871 Name: SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Sem. type: gngm|gngm|aapp Novel: true

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dehydroepiandrosterone INHIBITS SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Correct? #Y/N
A kinetic study revealed that DHEA acted as a non-competitive inhibitor of 11beta-HSD1 . (PMID: 21945397) 0/0
The adrenal sex steroid precursor dehydroepiandrosterone (DHEA) has been shown to inhibit 11beta-HSD1 in murine adipocytes; (PMID: 24022868) 0/0
Furthermore, we show potent and dose-dependent inhibition of 11beta-HSD1 by 7-keto-DHEA in differentiated human THP-1 macrophages and in HEK-293 cells overexpressing 11beta-HSD1 with or without H6PDH. (PMID: 19010388) 0/0
These results indicate that the inhibition of 11beta-HSD1 by DHEA depends on neither the transcriptional pathway nor the nonspecific manner. (PMID: 21945397) 0/0
This study shows that in a single population of whole-cells, with a highly reductive environment, 7alpha-OH-DHEA is unable to block the reducing activity of 11beta-HSD1 , and that 7-hydroxylation of DHEA does not interfere with the activation of glucocorticoids. (PMID: 23851218) 0/0