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Subject cui: 9181|56731 Name: ARHGEF2|SLC2A4RG Sem. type: gngm|gngm Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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ARHGEF2|SLC2A4RG STIMULATES CDC42|CDC42 gene Correct? #Y/N
The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16 , which activates Cdc42 . (PMID: 21139582) 0/0
In vitro kinetic analysis confirmed that recombinant ARHGEF16 activates Cdc42 and this was increased by the addition of recombinant Tip-1 and E6. (PMID: 21139582) 0/0
CONCLUSION: These data suggest that HPV16 E6, Tip-1 and ARHGEF16 may cooperate to activate Cdc42 and support a potential link between the expression of HPV16 E6 and Cdc42 activation. (PMID: 21139582) 0/0
The results suggest that Ral, GEFmeso and Cdc42 act in the same developmental pathway and that GEFmeso mediates activation of Cdc42 in response to activated Ral in the context of Drosophila wing development. (PMID: 16581976) 0/0
Cells expressing HPV16 E6 had higher levels of Cdc42 activation, which was decreased by siRNA silencing of either Tip-1 or ARHGEF16. (PMID: 21139582) 0/0