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Subject cui: C0006812 Name: Camptothecin Sem. type: orch Novel: true

Predicate: STIMULATES

Object cui: C1332120|545 Name: ATR|ATR gene Sem. type: gngm|gngm Novel: true

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Camptothecin STIMULATES ATR|ATR gene Correct? #Y/N
PP5(-/-) mouse embryonic fibroblasts demonstrated increased sensitivity to UV light, hydroxyurea, and camptothecin , which are known activators of ATR (ataxia-telangiectasia and Rad3-related) kinase. (PMID: 21921034) 0/0
Fhit-deficient cells show enhanced resistance to UVC, mitomycin C, camptothecin and ionizing radiation-induced cell killing, possibly due to strong activation of the ATR pathway following DNA damage; (PMID: 17457056) 0/0
To understand how signaling pathways impact this mechanism, an RNA interference screen in Drosophila S2 cells was used to identify proteins that regulate TAF1 (TBP-associated factor 1) alternative splicing in response to activation of the ATR (ATM-RAD3-related) signaling pathway by the chemotherapeutic drug camptothecin (CPT). (PMID: 19218244) 0/0
Moreover, we show that the key resection factor CtIP was dispensable for initial ATR-CHK1 activation after DNA damage by camptothecin and ionizing radiation. (PMID: 22733999) 0/0