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Subject cui: C0056693 Name: Cyclic ADP-Ribose Sem. type: bacs Novel: true

Predicate: STIMULATES

Object cui: C0055966|7226 Name: TRPM2|Clusterin Sem. type: gngm|aapp Novel: true

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Cyclic ADP-Ribose STIMULATES TRPM2|Clusterin Correct? #Y/N
We also show that, even though cyclic ADP-ribose (cADPR) does not activate TRPM2 at 25 degrees C, co-application of heat and intracellular cADPR dramatically potentiates TRPM2 activity. (PMID: 16601673) 0/0
We also show that, even though cyclic ADP-ribose (cADPR) does not activate TRPM2 at 25 degrees C, co-application of heat and intracellular cADPR dramatically potentiates TRPM2 activity. (PMID: 16601673) 0/0
Finally, adenosine diphosphoribose (ADPR) a breakdown product of both NAD and cADPR activates a plasma membrane cation channel termed TRPM2 thereby facilitating calcium (and sodium) entry into T cells. (PMID: 24009611) 0/0
We report here that, in HeLa cells, intracellular adenosine diphosphate ribose (ADPr) and cyclic ADPr (cADPr), as supposed activators of TRPM2, elicited cation currents that were virtually identical to the osmotic activation of HICCs. (PMID: 22219339) 0/0
Both cADPR and NAADP activate TRPM2 , albeit with lower efficacy than in the presence of subthreshold levels of ADPR (100nM), which significantly shifts the EC(50) for cADPR from 44 to 3muM and for NAADP from 95 to 1microM. (PMID: 18572241) 0/0
Here, we show that the two Ca2+-mobilizing second messengers cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) strongly activate natively expressed TRPM2 channels in Jurkat T cells. (PMID: 16585058) 0/0
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. (PMID: 16601673) 0/0
Other TRPM2 regulators include cADPR , NAADP and H(2)O(2), which synergize with ADPR to potentiate TRPM2 activation . (PMID: 18572241) 0/0