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Subject cui: C0008024 Name: Chenodeoxycholic Acid Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C0909868|26206|26871 Name: SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Sem. type: gngm|gngm|aapp Novel: true

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Chenodeoxycholic Acid INHIBITS SPAG8|RNU1-1|11-beta-Hydroxysteroid Dehydrogenase Type 1 Correct? #Y/N
In vitro, 11beta-HSD1 is selectively inhibited by chenodesoxycholic acid (CDCA) and upregulated under GC exposure. (PMID: 20925019) 0/0
In each case, CDCA functioned as a potent inhibitor of 11beta-HSD1 dehydrogenase with IC(50) values of ranging from 0.2 to 7 micromol/L in contrast to 37 to 200 micromol/L for 11beta-HSD1 reductase. (PMID: 15164334) 0/0
and (3) inhibition of 11beta-HSD1 dehydrogenase in aortic rings by CDCA (1 micromol/L) enhances the contractile response of corticosterone plus PE. (PMID: 15164334) 0/0