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Subject cui: C0919524|472 Name: ATM|ATM gene Sem. type: gngm|gngm Novel: true

Predicate: STIMULATES

Object cui: C1332120|545 Name: ATR|ATR gene Sem. type: gngm|gngm Novel: true

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ATM|ATM gene STIMULATES ATR|ATR gene Correct? #Y/N
While the levels of activated ATM in response to IR did not differ between TLR9-stimulated and unstimulated cells, inhibition of ATM/ATR and Chk1/Chk2 kinases abolished the radioprotective effects in TLR9-stimulated cells. (PMID: 18086870) 0/0
Indeed, while ATM activity constitutes a barrier to malignant transformation, full activation of ATR and CHK1 is essential for tumor maintenance, providing important opportunities for therapeutic intervention. (PMID: 22373487) 0/0
We observed similar upregulation of the ATR-CHEK1 pathway in a subset of oral squamous cell carcinoma (OSCC) cell lines with ATM loss. (PMID: 24142626) 0/0
We demonstrated that the human Rad50 hook mutants are severely defective in various DNA damage responses including ATM (Ataxia telangiectasia mutated) activation, homologous recombination, sensitivity to IR, and activation of the ATR pathway. (PMID: 22833675) 0/0
We found that hundreds of genes are upregulated in response to gamma-irradiation, and that the induction of virtually all of these genes is dependent on ATM, but not ATR. (PMID: 17227549) 0/0
ATM is critical for the initial response and the subsequent ATR activation . (PMID: 19285939) 0/0