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Subject cui: C1334862|4683|55655 Name: NBN|NLRP2|NBS1 gene Sem. type: gngm|gngm|gngm Novel: true


Object cui: C1332120|545 Name: ATR|ATR gene Sem. type: gngm|gngm Novel: true

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NBS1 directly activates ATR independently of MRE11 and TOPBP1. (PMID: 23368512) 0/0
The results of in vitro ATR kinase assay indicated that the N-terminal region of NBS1 directly activates ATR independently of TOPBP1, consistent with the findings that this region of NBS1 directly interacts with ATR. (PMID: 23368512) 0/0
These results therefore indicate that NBS1 and TOPBP1 have the potential to activate ATR independently, although both are required for functional activation of ATR in vivo. (PMID: 23368512) 0/0
First, both Mre11 and Nbs1 are required for facilitating ATR activation when Cdt1 is overexpressed, which in turn suppresses rereplication. (PMID: 17715134) 0/0
We find that MRN is involved in Rad3 (ATR)-dependent checkpoint signaling in S phase, but not G2, suggesting that MRN is involved in ATR activation through its role in replication fork metabolism. (PMID: 20065069) 0/0
Consistent with its role in ATR activation, HCLK2 depletion severely impaired phosphorylation of multiple ATR targets including Chk1, Nbs1, and Smc1 after DNA damage. (PMID: 19097996) 0/0
We found that CHK1 phosphorylation and FANCD2 ubiquitination induced by various DNA replication-stalling agents were abrogated in Nbs1 knockout DT40 cells but not in conditional Mre11 knockout cells, indicating an MRE11-independent role for NBS1 in ATR activation . (PMID: 23368512) 0/0
An Nbs1 mutant that is unable to bind RPA fails to support proper recovery of collapsed replication forks, suggesting that the Nbs1-mediated mode of ATR activation is important for the repair of replication-associated DSBs. (PMID: 23684611) 0/0
The MRN complex (Mre11/Rad50/Nbs1 ) is important in double-strand break (DSB) recognition, end resection, replication fork stabilization, and ATM and ATR activation . (PMID: 24388752) 0/0