At most 300 sentences shown!

Subject cui: C1328819 Name: small molecule Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C0140080|3480 Name: IGF1R|Insulin-Like-Growth Factor I Receptor Sem. type: gngm|aapp Novel: true

Sign in to evaluate.
small molecule INHIBITS IGF1R|Insulin-Like-Growth Factor I Receptor Correct? #Y/N
EXPERIMENTAL DESIGN: We analyzed IGF1R blockade by ADW742, a small molecule specific for this receptor, alone and in combination with imatinib, vincristine, and doxorubicin on Ewing tumor cell lines. (PMID: 16740780) 0/0
METHODS: We describe A-928605, a novel pyrazolo [3,4-d]pyrimidine small molecule inhibitor of the receptor tyrosine kinases (IGF1R and IR) responsible for IGF signal transduction. (PMID: 19732452) 0/0
METHODS: Ovaries from CD1 mice were cultured in alginate hydrogels in the presence or absence of 5 mug/ml insulin or IGF-I, as well as small molecule inhibitors of IR/IGF1R , PI 3-kinase signaling, or MAPK signaling. (PMID: 23388061) 0/0