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Subject cui: C0028128 Name: Nitric Oxide Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C1424661|10628 Name: TXNIP|TXNIP gene Sem. type: gngm|gngm Novel: true

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Nitric Oxide INHIBITS TXNIP|TXNIP gene Correct? #Y/N
Nitric oxide (NO), a repressor of TXNIP , enhanced insulin signal transduction, whereas inhibition of NO synthase abolished its activation, suggesting that TXNIP inhibition by NO is mediated by stimulation of insulin signalling. (PMID: 19214472) 0/0
Endogenously synthesized nitric oxide represses Txnip , thereby facilitating thioredoxin-mediated denitrosylation. (PMID: 19847012) 0/0
Promoter deletion analysis revealed that NO suppression of Txnip transcription is mediated by cis-regulatory elements between -1777 and -1127 bp upstream of the start codon. (PMID: 17023680) 0/0
AVS development may result from the loss of nitric oxide suppression of TXNIP expression. (PMID: 18585377) 0/0