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Subject cui: C0033684 Name: Proteins Sem. type: aapp Novel: true


Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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Proteins STIMULATES CDC42|CDC42 gene Correct? #Y/N
RhoA and Cdc42 were activated similarly by both gene products, but Rac1 was activated only by the mouse product. (PMID: 13679059) 0/0
We report here that secramine inhibits activation of the Rho GTPase Cdc42, a protein involved in membrane traffic, by a mechanism dependent upon the guanine dissociation inhibitor RhoGDI. (PMID: 16408091) 0/0
Intracellularly, this protein interferes with the endogenous cadherin/catenin complex, inducing p120-catenin delocalization to the cytoplasm, and the consequent activation of Rac1/Cdc42 and associated alterations in the actin cytoskeleton. (PMID: 22161837) 0/0
Unstable polarity was also observed in mutants lacking Bem1, a protein previously implicated in a feedback loop for Cdc42 activation through a signaling pathway. (PMID: 15353546) 0/0