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Subject cui: C0079419|7157 Name: TP53|TP53 gene Sem. type: gngm|gngm Novel: true

Predicate: STIMULATES

Object cui: C1417123|4233|8731|79811 Name: MET|RNMT|SLTM|MET gene Sem. type: gngm|gngm|gngm|gngm Novel: true

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TP53|TP53 gene STIMULATES MET|RNMT|SLTM|MET gene Correct? #Y/N
These murine CCAs bear histologic and genetic features of human intrahepatic CCA, including dense peritumoral fibrosis, increased inducible nitric oxide synthase, nitrotyrosine, and cyclooxygenase-2 expression, c-Met activation, cErbB2 overexpression, down-regulation of membrane-associated E-cadherin, and p53 codon 248 mutation. (PMID: 16818635) 0/0
It is becoming clear that the genetic mechanisms responsible for neoplastic transformation (activation of oncogenes such as RAS or MET, and inactivation of tumor suppressor genes such as p53 or PTEN) directly induce the expression of genes controlling hemostasis. (PMID: 19738115) 0/0
Furthermore, Met activation is increased upon combinatorial overexpression of epidermal growth factor receptor (EGFR) and p53(R175H), two common genetic mutations in ESCC. (PMID: 20534479) 0/0
We inhibited c-Met phosphorylation, resulting in diminished invasion of the genetically transformed primary esophageal epithelial cells (EPC-hTERT-EGFR-p53 (R175H) ), suggesting that the mechanism of increased invasiveness upon EGFR and p53 (R175H) expression may be the result of increased c-Met activation . (PMID: 23792586) 0/0
We inhibited c-Met phosphorylation, resulting in diminished invasion of the genetically transformed primary esophageal epithelial cells (EPC-hTERT-EGFR-p53 (R175H) ), suggesting that the mechanism of increased invasiveness upon EGFR and p53 (R175H) expression may be the result of increased c-Met activation . (PMID: 23792586) 0/0