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Subject cui: C0039601 Name: Testosterone Sem. type: horm Novel: true

Predicate: INHIBITS

Object cui: C0147139|7057 Name: THBS1|Thrombospondin 1 Sem. type: gngm|aapp Novel: true

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Testosterone INHIBITS THBS1|Thrombospondin 1 Correct? #Y/N
In the search for androgen target genes responsible for malignant growth in S115 mouse mammary tumor cells we found that thrombospondin 1 (TSP1) expression was strongly downregulated by testosterone (Te). (PMID: 16723184) 0/0
Experiments with cycloheximide suggested that Te repression of TSP1 was dependent on de novo protein synthesis. (PMID: 16723184) 0/0
TSP1 repression by Te was preceded by the induction of fibroblast growth factor 8 (FGF8) expression. (PMID: 16723184) 0/0