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Subject cui: 64857 Name: PLEKHG2 Sem. type: gngm Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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PLEKHG2 STIMULATES CDC42|CDC42 gene Correct? #Y/N
PLEKHG2 promotes heterotrimeric G protein betagamma-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization. (PMID: 24001768) 0/0
PLEKHG2/FLJ00018 , a Rho family-specific guanine nucleotide exchange factor (RhoGEF), is activated by heterotrimeric GTP-binding protein (G protein) Gbetagamma subunits, and in turn activates the small G protein Rac and Cdc42 , which have been shown to mediate signaling pathways leading to actin cytoskeletal reorganization. (PMID: 24378532) 0/0
These results provide evidence for a signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018. (PMID: 18045877) 0/0
Together, our studies have provided the first evidence for the endogenous function of PLEKHG2 , which may serve as a key Gbetagamma-stimulated RhoGEF that regulates lymphocyte chemotaxis via Rac and Cdc42 activation and actin polymerization. (PMID: 24001768) 0/0