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Subject cui: C1099354 Name: RNA, Small Interfering Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C1333928|3315 Name: HSPB1|HSPB1 gene Sem. type: gngm|gngm Novel: true

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RNA, Small Interfering INHIBITS HSPB1|HSPB1 gene Correct? #Y/N
The p38 MAPK inhibitor (SB-203580) and p38 MAPK siRNA blocked Hsp27 and Hsp70 mRNA induction, suggesting a role for MAPKs in the HEMEC heat shock response. (PMID: 16790501) 0/0
We have used small interfering RNAs to suppress HSP27 expression in HeLa cells and fibroblasts and found that it is required for pro-inflammatory cell signaling and the expression of pro-inflammatory genes. (PMID: 17202147) 0/0
siRNA inhibited Hsp27 expression in cell lines and improved the sensitivity of 17AAG. (PMID: 23469976) 0/0
Moreover, downregulation of Hsp27 by small interfering RNA in epithelial cells expressing DLK was accompanied by attenuated expression of involucrin in the cytoskeleton. (PMID: 19675578) 0/0