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Subject cui: C0694891|4089 Name: SMAD4|SMAD4 gene Sem. type: gngm|gngm Novel: true


Object cui: C0022457|3845 Name: KRAS|K-ras Oncogene Sem. type: gngm|gngm Novel: true

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SMAD4|SMAD4 gene STIMULATES KRAS|K-ras Oncogene Correct? #Y/N
Inactivation of Smad4 accelerates Kras (G12D)-mediated pancreatic neoplasia. (PMID: 17804724) 0/0
Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis. (PMID: 24386371) 0/0
SMAD4 deficiency also accelerated PDAC development of KRAS (G12D) INK4A/ARF heterozygous mice and altered the tumor phenotype; (PMID: 17114584) 0/0
Multiple combinations of genetic alterations are known to occur in PDAC including mutational activation of KRAS, inactivation of p16/CDKN2A and SMAD4 (DPC4) and dysregulation of PTEN/PI3K/AKT signaling. (PMID: 23316479) 0/0