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Subject cui: C1099354 Name: RNA, Small Interfering Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: 468 Name: ATF4 Sem. type: gngm Novel: true

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RNA, Small Interfering INHIBITS ATF4 Correct? #Y/N
Knockdown of ATF4 expression using siRNA suppressed ATF4 expression and phosphorylation of AKT1, MTOR and RPS6KB2, but increased LC3-II conversion. (PMID: 22722716) 0/0
FTS also induced an increase in p-PERK, while small interfering RNA to PERK reduced Nrf2 and ATF4 and rescued cells from FTS-induced death. (PMID: 19998334) 0/0
Overexpression of ATF4 upregulated the expression of Redd1, while suppression of ATF4 expression by siRNA enhanced the level of S6 phosphorylation by downregulating the SP600125-induced increase in Redd1 expression. (PMID: 19059405) 0/0
Both the ATF4 and ATF6 pathways were activated by celecoxib, and suppression of ATF4 and ATF6 mRNA expression by small interfering RNA (siRNA) inhibited the celecoxib-dependent up-regulation of ORP150. (PMID: 17167033) 0/0