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Subject cui: C0012935 Name: DNA, Single-Stranded Sem. type: bacs Novel: true


Object cui: C1332120|545 Name: ATR|ATR gene Sem. type: gngm|gngm Novel: true

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DNA, Single-Stranded STIMULATES ATR|ATR gene Correct? #Y/N
One model proposes that ATR can directly recognize DNA lesions, while other recent data suggest that ATR is activated by a common single-stranded DNA (ssDNA) intermediate generated during DNA repair. (PMID: 14742437) 0/0
ATM and DNA-PKcs respond mainly to DNA double-strand breaks, whereas ATR is activated by single-stranded DNA and stalled DNA replication forks. (PMID: 15758953) 0/0
The kinase ATR is activated by RPA-coated single-stranded DNA generated at aberrant replicative structures and resected double strand breaks. (PMID: 24038466) 0/0
Single-stranded DNA , a result of stalled DNA replication or processing of chromosomal lesions, appears to be central to the activation of ATR . (PMID: 15615778) 0/0
Further characterization of cell lines derived from the SCKL2 family revealed defective DNA damage induced formation of single-stranded DNA , a critical co-factor for ATR activation . (PMID: 21998596) 0/0