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Subject cui: C0037982 Name: Spironolactone Sem. type: phsu Novel: true

Predicate: INHIBITS

Object cui: 6446 Name: SGK1 Sem. type: gngm Novel: true

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Spironolactone INHIBITS SGK1 Correct? #Y/N
All parameters, including peritoneal thickening, number of macrophages and CD31-positive vessels, and expression of monocyte chemoattractant protein-1, TGF-beta, PAI-1, and Sgk1, were significantly suppressed by spironolactone (10 mg x kg(-1) x day(-1)). (PMID: 18353870) 0/0
Spironolactone also reduced the elevated SGK-1 expression in isoproterenol-treated rats. (PMID: 22327331) 0/0
The mineralocorticoid receptor inhibitor spironolactone decreased the mRNA levels of sgk , p21/waf1, and gadd45, whereas the glucocorticoid receptor inhibitor RU 486 reduced the mRNA level of sgk and p21/waf1. (PMID: 12969137) 0/0