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Subject cui: C0038317 Name: Steroids Sem. type: strd Novel: true

Predicate: INHIBITS

Object cui: C0525734|26206|26871 Name: SPAG8|RNU1-1|17beta HSD1 Sem. type: gngm|gngm|aapp Novel: true

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Steroids INHIBITS SPAG8|RNU1-1|17beta HSD1 Correct? #Y/N
The parallel synthesis of novel focused libraries of 16-substituted estrone derivatives and modified E-ring pyrazole steroids as new potent 17beta-HSD1 inhibitors is described. (PMID: 16892382) 0/0
Using a structure- and ligand-based approach, a pharmacophore model was proposed and a new class of non-steroidal inhibitors of 17beta-HSD1 was designed. (PMID: 18950679) 0/0
In the past, several steroidal and non-steroidal inhibitors of 17beta-HSD1 have been described but so far there is no cocrystal structure of the latter in complex with 17beta-HSD1. (PMID: 21857977) 0/0
Our results contribute to the knowledge of an unexpected observation: the C17-ketone steroidal inhibitors of 17beta-HSD1 are less potent than their corresponding C17-alcohol derivatives. (PMID: 19003559) 0/0