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Subject cui: C0915196 Name: KNK 437 Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: 3303 Name: HSPA1A Sem. type: gngm Novel: true

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KNK 437 INHIBITS HSPA1A Correct? #Y/N
RESULTS: KNK437 inhibited the expression of inducible hsp72 and hsp27, but produced no change in the mobility shift of HSF-1. (PMID: 16368649) 0/0
In the fractionated heat treatment, preheating (43 degrees C, 30 min) suppressed the increase in the number of the granules during the second heating, but suppression of Hsp72 by KNK437 resulted in increase in the number of granules. (PMID: 14643030) 0/0
Heat tolerance is suppressed by KNK437 through the suppression of heat-induced accumulations of hsp27 and hsp72 and the induction of p53-independent apoptosis. (PMID: 15370972) 0/0
Prior inhibition of HSP72 transcription with the pharmacological inhibitor KNK437 eliminated the ability of heat treatment to blunt JNK activation. (PMID: 21148343) 0/0