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Subject cui: C1366394|6776 Name: STAT5A|STAT5A protein, human Sem. type: gngm|aapp Novel: true

Predicate: INHIBITS

Object cui: C0599933|5970|6857|64689|65125 Name: RELA|SYT1|GORASP1|WNK1|p65 Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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STAT5A|STAT5A protein, human INHIBITS RELA|SYT1|GORASP1|WNK1|p65 Correct? #Y/N
Exposure to IFN-gamma mainly affects nuclear IRF-1 and STAT1 in EMT6, but inhibits NF-kappaB p65 activity, indicating that the cooperative stimulation was the result of the independent activation of NF-kappaB, STAT1 and IRF-1 transcriptional factors through binding to their unique sites in the UPase promoter. (PMID: 20544543) 0/0
CONCLUSIONS: GS inhibits the expression of the ICAM-1 gene in ARPE-19 cell stimulated with TNF-alpha or IFN-gamma through blockade of NF-kappaB subunit p65 and nuclear translocation of STAT1. (PMID: 16431966) 0/0
Small interfering RNA-mediated suppression of NF-kappaB p65 markedly inhibited the ability of cytokines to induce the expression of the CXCL10 gene, whereas targeting STAT1 only diminished the synergy provided by IFN-gamma. (PMID: 23740952) 0/0