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Subject cui: C0071163|116|51237 Name: ADCYAP1|MZB1|pituitary adenylate cyclase activating polypeptide Sem. type: gngm|gngm|aapp Novel: true

Predicate: STIMULATES

Object cui: C0904504|117|1316|1844|8624 Name: ADCYAP1R1|KLF6|DUSP2|PSMG1|Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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ADCYAP1|MZB1|pituitary adenylate cyclase activating polypeptide STIMULATES ADCYAP1R1|KLF6|DUSP2|PSMG1|Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I Correct? #Y/N
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) exert their actions via common receptors, VPAC1 and VPAC2, which are equally sensitive to both peptides, while PACAP stimulates its specific PAC1-type receptors . (PMID: 16888226) 0/0
Pituitary adenylate cyclase-activating polypeptide (PACAP ) and vasoactive intestinal peptide (VIP) exert their actions via common receptors, VPAC1 and VPAC2, which are equally sensitive to both peptides, while PACAP stimulates its specific PAC1-type receptors . (PMID: 16888226) 0/0
Strategies to overcome these compromising conditions include the development of metabolically stable analogs of PACAP acting as selective agonists of the PAC1 receptor . (PMID: 19835562) 0/0
PACAP treatment attenuates neuronal cell loss in diabetic retinopathy, the protective effects of PACAP probably being mediated through the activation of PAC1-receptor . (PMID: 22350850) 0/0
Moreover, PACAP increased the levels of PAC1-receptor and tyrosine-hydroxylase as detected by molecular biological methods. (PMID: 22350850) 0/0
This review presents an overview of the structure-activity relationships of PACAP and summarizes the molecular and conformational requirements for activation of PAC1 receptor . (PMID: 19835562) 0/0