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Subject cui: C0286651 Name: atorvastatin Sem. type: orch Novel: true

Predicate: INHIBITS

Object cui: C0006560|1401 Name: CRP|C-reactive protein Sem. type: gngm|aapp Novel: true

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atorvastatin INHIBITS CRP|C-reactive protein Correct? #Y/N
Atorvastatin lowered plasma CRP from 5.16+/-1.9 to 2.88+/-1.06 mg/L (p<0.001) and MMP-9 activity from 64.3+/-28.1 to 35.4+/-20.0 ng/ml (p<0.0001). (PMID: 15247960) 0/0
While atorvastatin decreased hs-CRP levels in both genotype groups (P<0.05), no significant effects were found on the concentrations of sICAM-1, MCP-1, pro-MMP-9, pro-MMP-2 and TIMP-1. (PMID: 16938300) 0/0
After the atorvastatin dose was increased, significant reductions in CRP , F1+2, and PAI-1 levels were observed (P<.05). (PMID: 16053827) 0/0
Although no significant effect was seen on oxidative stress, 2 of 4 inflammatory markers, IL-6 (adjusted OR: 0.59, 95% CI: 0.35-0.97, P = 0.04) and hs-CRP (adjusted OR: 0.59, 95% CI: 0.37-0.95, P = 0.03) were significantly lowered with atorvastatin. (PMID: 20946227) 0/0
CONCLUSION: HMG-CoA-reductase inhibitor atorvastatin more effectively lowers concentration of CRP in blood plasma of patients with PA than with IHD what possibly is explained by higher initial level of this marker of inflammatory processes. (PMID: 18991814) 0/0
Atorvastatin was much more effective than lovastatin, while CRP reduction was not significant by simvastatin. (PMID: 21189431) 0/0