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Subject cui: C1099354 Name: RNA, Small Interfering Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C1332712|960 Name: CD44|CD44 gene Sem. type: gngm|gngm Novel: true

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RNA, Small Interfering INHIBITS CD44|CD44 gene Correct? #Y/N
CD44 expression was downregulated with siRNAs followed by treatment with different concentrations of the antitumor drug. (PMID: 21792314) 0/0
This was dependent on the expression of CD44 and was inhibited by CD44-specific siRNA. (PMID: 21864707) 0/0
Methods: In primary murine chondrocytes CD44 expression was decreased by siRNA or enhanced by plasmid transfection. (PMID: 24497488) 0/0
METHODS: CD44 gene expression in cells was suppressed by siRNA which was introduced into cells through retrovirus infection. (PMID: 17380671) 0/0
Inhibition of CD44 expression by small interfering RNA to suppress the growth and metastasis of ovarian cancer cells in vitro and in vivo. (PMID: 19393131) 0/0
In conclusion, downregulation of CD44 expression by siRNA inhibits the in vitro adhesion, invasion and resistance to apoptosis of ovarian cancer cells, suppresses tumour growth and peritoneal dissemination of human ovarian cancer xenograft in nude mice. (PMID: 19393131) 0/0
Whereas CD44 small interfering RNA (siRNA) transfection decreased cell growth and induced apoptosis in HT1376 cells, HA addition modestly increased CD44 expression and cell growth in HAS1-AS transfectants, which could be blocked by CD44 siRNA. (PMID: 18199543) 0/0
Inhibition of malignant activities of nasopharyngeal carcinoma cells with high expression of CD44 by siRNA. (PMID: 17611662) 0/0
Targeted Nanomedicine for Suppression of CD44 and Simultaneous Cell Death Induction in Ovarian Cancer: An Optimal Delivery of siRNA and Anticancer Drug. (PMID: 24036854) 0/0