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Subject cui: C0020281 Name: Hydrogen Peroxide Sem. type: inch Novel: true


Object cui: C0055966|7226 Name: TRPM2|Clusterin Sem. type: gngm|aapp Novel: true

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Hydrogen Peroxide STIMULATES TRPM2|Clusterin Correct? #Y/N
TRPM2 is activated by hydrogen peroxide; (PMID: 21291387) 0/0
TRPM2 is a Ca2+ -permeable nonselective cation channel activated by intracellular ADP-ribose (ADPR) and by hydrogen peroxide (H2O2). (PMID: 16604090) 0/0
Moreover, patch-clamp recordings from C13 demonstrated that increased intracellular adenosine diphosphoribose (ADPR) or extracellular H2O2 induced an inward current, consistent with activation of TRPM2 . (PMID: 16777714) 0/0
Application of hydrogen peroxide or peroxynitrite to cultured hippocampal pyramidal neurons activated an inward current that was abolished upon removal of extracellular Ca(2+), a hallmark of TRPM2 activation . (PMID: 19124544) 0/0