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Subject cui: C1099354 Name: RNA, Small Interfering Sem. type: bacs Novel: true

Predicate: INHIBITS

Object cui: C0599933|5970|6857|64689|65125 Name: RELA|SYT1|GORASP1|WNK1|p65 Sem. type: gngm|gngm|gngm|gngm|aapp Novel: true

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RNA, Small Interfering INHIBITS RELA|SYT1|GORASP1|WNK1|p65 Correct? #Y/N
The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100nmol/L) in the human endothelial cell line EA. (PMID: 24513509) 0/0
The specific NF-kappa B inhibitor pyrrolidine dithiocarbamate- (PDTC-) or small interfering RNA directed against NF-kappa B p65-mediated downregulation of NF-kappa B p65 was further enhanced by REV (100 nmol/L) in the human endothelial cell line EZ.hy926. (PMID: 24436987) 0/0
CREB siRNA suppressed indoxyl sulfate-induced NF-kappaB p65 expression, whereas both NF-kappaB inhibitors and NF-kappaB p65 siRNA prevented indoxyl sulfate-induced CREB expression. (PMID: 23407882) 0/0
We found that p65 siRNA could effectively reduce the p65 mRNA and protein expression, arrest cells in G0/G1 phase, inhibit the proliferation and increase the apoptosis of THP-1 cells, and intratumoral injection of p65 siRNA could suppress tumor growth in nude mice. (PMID: 21901538) 0/0
TNFalpha increased HSP60 expression, and this could be prevented by pretreatment with siRNA inhibiting p65 expression. (PMID: 19945465) 0/0
RESULTS: DNA-binding avtivity as well as COX-2 mRNA and protein expression were strongly inducible by IL-1beta treatment in OVCAR-3 cells, while p65 siRNA inhibited IL-1beta-dependent p65 activity (p = 0.037) as well as COX-2 expression on the mRNA (p < 0.03) and on the protein level. (PMID: 18314621) 0/0
Inhibition of p65 by p65 siRNA decreased PUMA expression of doxorubicin-induced. (PMID: 24065225) 0/0
Immunohistochemistry, RT-PCR and TUNEL assay showed that p65 siRNA downregulated the expression of p65 and enhanced the sensitivity of EC9706 cells to 5-FU treatment in vivo. (PMID: 22186294) 0/0
Inhibition of p65 expression by siRNA significantly decreases C/EBPbeta-binding and LTR expression. (PMID: 17031851) 0/0
Inhibition of NF-kappaB by the pharmacologic inhibitor curcumin (20 microM) or suppression of p65 by siRNA resulted in a significant increase in cell death in response to cigarette smoke exposure. (PMID: 18811964) 0/0
Under these conditions, application of siRNA /in vivo-jetPEI complexes from the jugular vein successfully suppressed NF-kappaB p65 expression in the heart. (PMID: 20852747) 0/0
This change was exerted at the transcriptional level because the inhibition of nuclear factor kappa B translocation by small interfering RNA against p65 and SN-50 prevented oxygen and glucose deprivation-induced NCX1 upregulation. (PMID: 19164785) 0/0
The involvement of signaling pathways was further confirmed by the inhibition of proliferation by knockdown of ERK1/2 MAPK or NF-kappaB p65 expression with pathway-specific siRNA. (PMID: 22898922) 0/0
The inhibition of NF-kappaB-p65 expression and activity (by p65 short interfering RNA (siRNA) and pyrrolidine dithiocarbamate, respectively) in chondrocytes reversed the proepithelin-mediated induction of cell proliferation and differentiation and the proepithelin-mediated prevention of cell apoptosis. (PMID: 21566130) 0/0