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Subject cui: C0080059|6714 Name: SRC|Proto-Oncogene Protein pp60 (c-src) Sem. type: gngm|aapp Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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SRC|Proto-Oncogene Protein pp60 (c-src) STIMULATES CDC42|CDC42 gene Correct? #Y/N
The EGF-stimulated activation of Cdc42 does require activated Src, as well as the Vav2 protein, a member of the Dbl family of guanine nucleotide exchange factors. (PMID: 14506284) 0/0
These results indicate that the trans-interactions of Necl-5 and nectin-3 and of nectin and nectin induce the activation of Cdc42 and Rac through the common signaling molecules c-Src, Rap1, FRG, and Vav2. (PMID: 16128743) 0/0
This work reveals a multicomponent kinase signaling pathway downstream of integrin-matrix interactions and Cdc42 activation involving PKCepsilon, Src, Yes, Pak2, Pak4, B-Raf, C-Raf and ERK1/2 to control EC lumen formation in 3D collagen matrices. (PMID: 19435802) 0/0