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Subject cui: C0671110|11073 Name: TOPBP1|DNA topoisomerase II binding protein Sem. type: gngm|aapp Novel: true

Predicate: STIMULATES

Object cui: C1332120|545 Name: ATR|ATR gene Sem. type: gngm|gngm Novel: true

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TOPBP1|DNA topoisomerase II binding protein STIMULATES ATR|ATR gene Correct? #Y/N
TopBP1 has been identified as a direct activator of ATR . (PMID: 17446169) 0/0
TopBP1 functions as a general activator of ATR . (PMID: 18519640) 0/0
We have recently shown that TopBP1 activates ATR through its regulatory subunit ATRIP and a PIKK regulatory domain (PRD) located adjacent to its kinase domain. (PMID: 18769153) 0/0
TopBP1 functions as a general activator of ATR . (PMID: 18769153) 0/0
Previous studies have shown that ATR is recruited via its binding partner ATR-interacting protein (ATRIP) to replication protein A (RPA)-covered single-stranded DNA (RPA-ssDNA) generated at sites of DNA damage where ATR is then activated by TopBP1 to phosphorylate downstream targets including the Chk1 signal transducing kinase. (PMID: 20616048) 0/0
A recent report from this laboratory demonstrated that TopBP1 functions as an activator of ATR . (PMID: 16760665) 0/0
A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1. (PMID: 19464966) 0/0
Importantly, our results suggest that HCLK2 functions in the same pathway as TopBP1 but that the two proteins regulate different steps in ATR activation . (PMID: 19097996) 0/0
ATR activation requires several factors, including the BRCT repeat-containing TopBP1 protein and the 9-1-1 clamp protein. (PMID: 19652550) 0/0
In metazoans, only TopBP1 has been identified as a direct ATR activator . (PMID: 23950734) 0/0