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Subject cui: C0206364 Name: Receptor Protein-Tyrosine Kinases Sem. type: aapp Novel: true

Predicate: STIMULATES

Object cui: 4233|8731|79811 Name: MET|RNMT|SLTM Sem. type: gngm|gngm|gngm Novel: true

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Receptor Protein-Tyrosine Kinases STIMULATES MET|RNMT|SLTM Correct? #Y/N
To determine whether the lack of response of MET inhibitors was due to cooperation with other RTKs , we determined activation status of MET and other RTKs, including epidermal growth factor receptor (EGFR) family of 20 MPM cell lines, and tested whether dual RTK inhibition is an effective therapeutic strategy. (PMID: 19380521) 0/0
Phospho-RTK array analysis revealed that MET was simultaneously activated with other RTKs, including EGFR, ErbB2, ErbB3 and platelet-derived growth factor receptor-beta. (PMID: 19380521) 0/0
For example, hepatocyte growth factor (HGF), the ligand of a tyrosine kinase receptor Met, activates Met and the downstream PI3K/Akt pathway and triggers resistance to EGFR inhibitors in EGFR mutant lung cancer cells. (PMID: 22435662) 0/0
HGF-induced activation of c-Met, its receptor-tyrosine kinase, was observed in both melanocytes and melanoma cells, whereas phosphatidylinositol 3-kinase (PI3K), a downstream target of c-Met, was not activated in the melanocytes but enhanced in the melanoma cell lines. (PMID: 17625596) 0/0
Inappropriate activation of MET, the receptor tyrosine kinase for hepatocyte growth factor (HGF), has been implicated in tumorigenesis. (PMID: 16189274) 0/0
We also found that EGCG did not act on the intracellular portion of Met receptor tyrosine kinase , i.e., it inhibited InlB-dependent activation of Met but not NGF-induced activation of Trk-Met hybrid receptor. (PMID: 21209554) 0/0
Uncontrolled activation of MET, another tyrosine kinase receptor, has been implicated in neoplastic invasive growth. (PMID: 21443472) 0/0
Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase , whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, invasion, and metastasis of many types of solid tumors. (PMID: 20624990) 0/0
Analysis of phosphorylation of tyrosine kinase receptors showed a specific increase in c-Met activation . (PMID: 23799130) 0/0