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Subject cui: C0812234|387 Name: RHOA|RHOA gene Sem. type: gngm|gngm Novel: true

Predicate: STIMULATES

Object cui: C1366537|998 Name: CDC42|CDC42 gene Sem. type: gngm|gngm Novel: true

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RHOA|RHOA gene STIMULATES CDC42|CDC42 gene Correct? #Y/N
We show that following the coculture of previously healthy T cells with CLL cells, subsequent LFA-1 engagement leads to altered Rho GTPase activation signaling by downregulating RhoA and Rac1, while upregulating Cdc42 . (PMID: 23325833) 0/0
Therefore, we propose that RhoA may activate Cdc42 in parallel with an effector, such as p160Rho-kinase, that induces and maintains actin stress fibers in a dominant fashion. (PMID: 17712627) 0/0
These data highlight for the first time an integrated mechanism whereby CTGF regulates cell migration through facilitative actin cytoskeleton disassembly, which is mediated by dephosphorylation of focal adhesion kinase and paxillin, loss of RhoA activity, activation of Cdc42 , and phosphorylation of PKC-zeta and GSK-3beta. (PMID: 15319369) 0/0
Activation of Cdc42 was sufficient to decrease RhoA activity. (PMID: 18562481) 0/0
Furthermore, p120-catenin depletion inactivated RhoA , but increased the activity of Cdc42 and Rac1, and promoted proliferation and the invasive ability of lung cancer cells both in vitro and in vivo. (PMID: 19154401) 0/0
Thus, redox agents may function to downregulate RhoA activity under conditions that stimulate Rac1 and Cdc42 activity. (PMID: 17128987) 0/0
The pro- invasive 13mer peptide-signalling pathway implicates activation of Cdc42 and inactivation of RhoA, linked to each other through the serine/threonine p21- activated kinase 1. (PMID: 14609961) 0/0
Furthermore, our data indicated that NKG2D cross-linking induces the activation of the Rho GTPases Rac1 and Cdc42, while RhoA activity is decreased. (PMID: 22585739) 0/0
In accordance, overexpression of Dsg3 results in a remarkable increase of Rac1 and Cdc42 activities and to a lesser extent, RhoA. (PMID: 22796473) 0/0
Recent studies revealed that cAMP signalling, which is well known to be barrier protective, enhances barrier functions in part via Rap1-mediated activation of Rac1 and Cdc42 as well as by inhibition of RhoA. (PMID: 20299335) 0/0
Activation of RhoA, Rac1 and Cdc42 (CNF1), but not of RhoA alone (CNF(Y)), enhanced Listeria-dependent IL-8 release significantly. (PMID: 16884694) 0/0
Furthermore, culturing NSCs on increasingly stiff ECMs enhances RhoA and Cdc42 activation , increases NSC stiffness, and suppresses neurogenesis. (PMID: 21956892) 0/0
With the advent of fluorescence resonance energy transfer (FRET)-based Rho activity reporters, RhoA has been shown to be active at the leading edge of migrating cells where it precedes Rac and Cdc42 activation . (PMID: 24025634) 0/0